Everything has to be said two times.
One of the most exhausting aspects of the early stage of this illness is the resistance. While she is yet able to be self-determining, Mummy self-determines. To that end, she resists every instruction. [And yes, they are instructions because the higher order thinking is no longer there, so offering information in the hope that she will make appropriate decisions is wasted time.] So you ask/tell her to put in her eye drops and she resists; you ask/tell her to get changed, resistance; you ask her to take her medication, you guessed it, resistance. The trouble with this, and I've said this before, is that since she forgets the instruction if it isn't carried out immediately, the onus is on one of us to repeat, return or rerun the course.
I'm not going to lie, it gets to you sometimes.